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The overstimulation of neurons activates microglia, the resident immune cells of the brain, which release proinflammatory cytokines, such as TNF- and IL-1, as well as ROS (McConnell et al., 2015) (Figure 1)
The structures of the NK2 segment of HGF II can be superimposed well onto that of HGF I, suggesting that no domain rearrangements occur in this structural segment (Supplementary Fig
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